Routine testing is important for young, healthy people taking isotretinoin because it helps find problems that could be caused by the drug. Blood counts, liver function tests, and muscle function tests are the main types of tests. But because these tests can take a while to run, it's best to do routine tests at the start of treatment with isotretinoin.
Even though isotretinoin works very well, it can cause a number of problems, such as an increased risk of insulin resistance, a faster rate of atherosclerosis, and weight gain. Because of this, it is important to keep a close eye on patients to make sure they don't get these problems. During treatment with isotretinoin, blood tests are often used to check how well the liver is working, see how much fat is in the blood, and look for certain risk factors.
Lipid changes need to be checked for on a regular basis in young, healthy people who take isotretinoin. Patients whose levels of lipids at the start are higher than normal should be closely watched. Also, extra care should be taken with people who have hyperlipidemia.
The goal of this study was to find out what happens to liver enzymes when people take isotretinoin. Taking isotretinoin usually has less of an effect on liver enzymes than on lipid profiles. So, the authors did an analysis of repeated measures for AST, ALT, and AST/ALT. They also did a Cochran Q test to figure out how many abnormal lab values there were.
In eight patients, the mean AST level was too high. During the first follow-up, AST went up in a few other patients, but it wasn't a big deal. Also, it was seen that the number of high TGs kept going up over time. Several of these people had been taking isotretinoin for a year or more.
If a young, healthy person is taking isotretinoin, it may not be necessary to check their liver function regularly. Aberrations in liver function test results, on the other hand, are a sign of possible liver damage in people with severe liver disease. Also, these tests help doctors decide whether to keep giving isotretinoin or whether to change the dose or treatment plan.
These tests are used to find out how much protein and enzyme the liver makes. They are done on a single sample of blood. The underlying condition is worse if there are more tests that are above normal.
Most of the time, there were problems with the lipids in the blood. About one-third of patients had elevations that were mild to moderate. Some patients had high triglycerides, which can be caused by being overweight or by taking certain medicines. Serum aminotransferase was also higher than it should have been, which is a sign of liver damage.
In the study by Baykal Selcuk et al., they looked at how often sacroiliitis happened in people who took isotretinoin and in people who took a "control" drug. Even though the study didn't find any big differences in how often sacroiliitis happened, it's still important to keep an eye on it. Also, patients with sacroiliitis may be told to get an MRI as a follow-up.
In a second study, the effects of isotretinoin on muscle strength were looked at. On average, the drug was given to patients for three months. At each follow up, a physical exam was done on each patient. On the side that was not the dominant one, muscle strength was measured.
It is not common to test healthy young people who take isotretinoin for hepatitis on a regular basis. But this is one of the best medicines for acne, and it does have some risks. It should not be taken by women who are pregnant, and it can make liver enzymes rise even more if they are already high for other reasons.
Acne can be treated with a synthetic form of vitamin A called isotretinoin, which is sold under the brand name Accutane(r). The drug works by stopping the sebaceous gland and meibomian glands from making oil, which makes the skin dry. But it also has a lot of bad effects.
The most important thing is that you can use the medicine safely. It also works well to treat severe acne. Most of the time, it takes a few weeks to fully work. During the course of treatment, it's important to keep track of the dosage. This can be done by checking the blood and liver enzymes once a month. Stopping the medicine as soon as possible is especially important for women who are pregnant.